ADRA2A

GENE INFORMATION

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Gene name

ADRA2A (HGNC Symbol)

Synonyms

ADRA2, ADRA2R, ADRAR

Description

adrenoceptor alpha 2A (HGNC Symbol)

Entrez gene summary

Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in mouse revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons; the alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes alpha2A subtype and it contains no introns in either its coding or untranslated sequences. [provided by RefSeq, Jul 2008]

Chromosome

10 (Chromosome progress)

Cytoband

q25.2

Chromosome location (bp)

112836790 - 112840658

Ensembl

ENSG00000150594 (version 73.37)

Entrez gene

150

UniProt

P08913 (UniProt - Evidence at protein level)

neXtProt

NX_P08913

Antibodypedia

ADRA2A antibodies
 

PROTEIN VIEW

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ADRA2A-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ADRA2A-001 ENSP00000280155
ENST00000280155
P08913
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