DOCK1

GENERAL INFORMATION

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Gene name

DOCK1

Gene description

Dedicator of cytokinesis 1

Protein class

Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Mixed
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic expression in several cell types.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 2 antibodies.
HPA048692 , CAB004378
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Thyroid gland

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Mixed

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

DOCK1 (HGNC Symbol)

Synonyms

ced5, DOCK180

Description

Dedicator of cytokinesis 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the dedicator of cytokinesis protein family. Dedicator of cytokinesis proteins act as guanine nucleotide exchange factors for small Rho family G proteins. The encoded protein regulates the small GTPase Rac, thereby influencing several biological processes, including phagocytosis and cell migration. Overexpression of this gene has also been associated with certain cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

Chromosome

10

Cytoband

q26.2

Chromosome location (bp)

126905409 - 127452517

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000150760 (version 78.38)

Entrez gene

1793

UniProt

Q14185 (UniProt - Evidence at protein level)

neXtProt

NX_Q14185

Antibodypedia

DOCK1 antibodies


PROTEIN BROWSER

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ENST00000280333
 
ENST00000623213
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DOCK1-001 ENSP00000280333
ENST00000280333
Q14185
Show all »
Show » Show » 1865 215.3 No 0
DOCK1-006 ENSP00000485033
ENST00000623213
Show » Show » 1886 217.8 No 0