PTS

GENE INFORMATION

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Gene name

PTS (HGNC Symbol)

Synonyms

PTPS

Description

6-pyruvoyltetrahydropterin synthase (HGNC Symbol)

Entrez gene summary

The enzyme encoded by this gene catalyzes the elimination of inorganic triphosphate from dihydroneopterin triphosphate, which is the second and irreversible step in the biosynthesis of tetrahydrobiopterin from GTP. Tetrahydrobiopterin, also known as BH(4), is an essential cofactor and regulator of various enzyme activities, including enzymes involved in serotonin biosynthesis and NO synthase activity. Mutations in this gene result in hyperphenylalaninemia. [provided by RefSeq, Oct 2008]

Chromosome

11 (Chromosome progress)

Cytoband

q23.1

Chromosome location (bp)

112097088 - 112140678

Ensembl

ENSG00000150787 (version 73.37)

Entrez gene

5805

UniProt

Q03393 (UniProt - Evidence at protein level)

neXtProt

NX_Q03393

Antibodypedia

PTS antibodies
 

PROTEIN VIEW

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PTS-001
 
PTS-002
 
PTS-004
 
PTS-005
 
PTS-008
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PTS-001 ENSP00000280362
ENST00000280362
Q03393
Show all »
Show » Show » 145 16.4 No 0
PTS-002 ENSP00000433469
ENST00000531673
E9PKY8
Show all »
Show » 55 6.2 No 0
PTS-004 ENSP00000435895
ENST00000528679
E9PKY8
Show all »
Show » 55 6.2 No 0
PTS-005 ENSP00000431750
ENST00000525803
E9PJM0
Show all »
Show » 61 6.7 No 0
PTS-008 ENSP00000434688
ENST00000524931
E9PNN3
Show all »
Show » 77 8.9 No 0