CACNA1C

GENERAL INFORMATION

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Gene name

CACNA1C

Gene description

Calcium channel, voltage-dependent, L type, alpha 1C subunit

Protein class

Disease related genes
FDA approved drug targets
Predicted intracellular proteins
Predicted membrane proteins
Transporters
Voltage-gated ion channels

Predicted localization

Intracellular,Membrane

Number of transcripts

32
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (heart muscle, smooth muscle)
GTEx:Tissue enhanced (colon)

Protein evidence

Evidence at protein level

Protein localization

Membranous expression mainly in smooth muscle, endothelium and heart.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Data reliability

Supportive based on 1 antibody.
HPA039796
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Heart muscle

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (heart muscle, smooth muscle)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (colon)

Organ

Expression



GENE INFORMATION

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Gene name

CACNA1C (HGNC Symbol)

Synonyms

CACH2, CACN2, CACNL1A1, Cav1.2, CCHL1A1, LQT8, TS

Description

Calcium channel, voltage-dependent, L type, alpha 1C subunit (HGNC Symbol)

Entrez gene summary

This gene encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. There are multiple isoforms of each of these proteins, either encoded by different genes or the result of alternative splicing of transcripts. The protein encoded by this gene binds to and is inhibited by dihydropyridine. Alternative splicing results in many transcript variants encoding different proteins. Some of the predicted proteins may not produce functional ion channel subunits. [provided by RefSeq, Oct 2012]

Chromosome

12

Cytoband

p13.33

Chromosome location (bp)

1970786 - 2697950

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000151067 (version 78.38)

Entrez gene

775

UniProt

Q13936 (UniProt - Evidence at protein level)

neXtProt

NX_Q13936

Antibodypedia

CACNA1C antibodies


PROTEIN BROWSER

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ENST00000327702
 
ENST00000335762
 
ENST00000344100
 
ENST00000347598
 
ENST00000399591
 
ENST00000399595
 
ENST00000399597
 
ENST00000399601
 
ENST00000399603
 
ENST00000399606
 
ENST00000399617
 
ENST00000399621
 
ENST00000399629
 
ENST00000399634
 
ENST00000399637
 
ENST00000399638
 
ENST00000399641
 
ENST00000399644
 
ENST00000399649
 
ENST00000399655
 
ENST00000402845
 
ENST00000406454
 
ENST00000465278
 
ENST00000480911
 
ENST00000496818
 
ENST00000543114
 
ENST00000613940
 
ENST00000615303
 
ENST00000615400
 
ENST00000616390
 
ENST00000620878
 
ENST00000621625
 
 » 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CACNA1C-001 ENSP00000382563
ENST00000399655
Q13936
Show all »
Show » Show » 2138 239.6 No >9
CACNA1C-002 ENSP00000382504
ENST00000399595
Q13936
Show all »
Show » Show » 2146 240.4 No >9
CACNA1C-003 ENSP00000382552
ENST00000399644
Q13936
Show all »
Show » Show » 2138 239.5 No >9
CACNA1C-004 ENSP00000382547
ENST00000399638
Q13936
Show all »
Show » Show » 2166 242.8 No >9
CACNA1C-005 ENSP00000382506
ENST00000399597
Q13936
Show all »
Show » Show » 2138 239.7 No >9
CACNA1C-006 ENSP00000382530
ENST00000399621
Q13936
Show all »
Show » Show » 2157 241.6 No >9
CACNA1C-007 ENSP00000382546
ENST00000399637
Q13936
Show all »
Show » Show » 2157 241.5 No >9
CACNA1C-008 ENSP00000382500
ENST00000399591
Q13936
Show all »
Show » Show » 2146 240.3 No >9
CACNA1C-010 ENSP00000382549
ENST00000399641
Q13936
Show all »
Show » Show » 2138 239.5 No >9
CACNA1C-011 ENSP00000382512
ENST00000399603
Q13936
Show all »
Show » Show » 2138 239.7 No >9
CACNA1C-012 ENSP00000382542
ENST00000399634
E9PDI6
Show all »
Show » Show » 2209 247.1 No >9
CACNA1C-013 ENSP00000382526
ENST00000399617
Q86XX0
Show all »
Show » Show » 2173 243.7 No >9
CACNA1C-015 ENSP00000336982
ENST00000335762
F5H522
Show all »
Show » Show » 2163 242.4 No >9
CACNA1C-016 ENSP00000478996
ENST00000465278
Show » 243 27 No 2
CACNA1C-017 ENSP00000266376
ENST00000347598
Q13936
Show all »
Show » Show » 2186 245 No >9
CACNA1C-018 ENSP00000437936
ENST00000480911
F5H638
Show all »
Show » Show » 1279 144.7 No >9
CACNA1C-019 ENSP00000382515
ENST00000399606
Q13936
Show all »
Show » Show » 2158 241.9 No >9
CACNA1C-020 ENSP00000382510
ENST00000399601
Q13936
Show all »
Show » Show » 2138 239.5 No >9
CACNA1C-021 ENSP00000341092
ENST00000344100
Q13936
Show all »
Show » Show » 2179 243.7 No >9
CACNA1C-022 ENSP00000382537
ENST00000399629
Q13936
Show all »
Show » Show » 2155 241.5 No >9
CACNA1C-023 ENSP00000329877
ENST00000327702
Q86XX0
Show all »
Show » Show » 2173 243.5 No >9
CACNA1C-024 ENSP00000382557
ENST00000399649
Q13936
Show all »
Show » Show » 2144 240.2 No >9
CACNA1C-026 ENSP00000479274
ENST00000496818
Show » 144 17.3 No 2
CACNA1C-031 ENSP00000385896
ENST00000406454
F5GY28
Show all »
Show » Show » 2209 247.2 No >9
CACNA1C-032 ENSP00000385724
ENST00000402845
Q13936
Show all »
Show » Show » 2157 241.6 No >9
CACNA1C-034 ENSP00000445849
ENST00000543114
F5H0X0
Show all »
Show » Show » 100 10.4 No 0
CACNA1C-036 ENSP00000482910
ENST00000616390
O95234
Show all »
Show » Show » 829 91.5 No 3
CACNA1C-201 ENSP00000483335
ENST00000613940
Q86XX0
Show all »
Show » Show » 2014 226.5 No >9
CACNA1C-202 ENSP00000480922
ENST00000615303
Q86XX0
Show all »
Show » Show » 2062 231.8 No >9
CACNA1C-203 ENSP00000480292
ENST00000615400
Q86XX0
Show all »
Show » Show » 2027 227.9 No >9
CACNA1C-204 ENSP00000479029
ENST00000620878
Q86XX0
Show all »
Show » Show » 2039 228.8 No >9
CACNA1C-205 ENSP00000484796
ENST00000621625
Q86XX0
Show all »
Show » Show » 2014 226.3 No >9