CACNA1C

GENE INFORMATION

? »

Gene name

CACNA1C (HGNC Symbol)

Synonyms

CACH2, CACN2, CACNL1A1, Cav1.2, CCHL1A1, LQT8, TS

Description

calcium channel, voltage-dependent, L type, alpha 1C subunit (HGNC Symbol)

Entrez gene summary

This gene encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. There are multiple isoforms of each of these proteins, either encoded by different genes or the result of alternative splicing of transcripts. The protein encoded by this gene binds to and is inhibited by dihydropyridine. Alternative splicing results in many transcript variants encoding different proteins. Some of the predicted proteins may not produce functional ion channel subunits. [provided by RefSeq, Oct 2012]

Chromosome

12 (Chromosome progress)

Cytoband

p13.33

Chromosome location (bp)

2079952 - 2802108

Ensembl

ENSG00000151067 (version 73.37)

Entrez gene

775

UniProt

Q13936 (UniProt - Evidence at protein level)

neXtProt

NX_Q13936

Antibodypedia

CACNA1C antibodies
 

PROTEIN VIEW

? »
 
 
 « 
 
CACNA1C-001
 
CACNA1C-002
 
CACNA1C-003
 
CACNA1C-004
 
CACNA1C-005
 
CACNA1C-006
 
CACNA1C-007
 
CACNA1C-008
 
CACNA1C-010
 
CACNA1C-011
 
CACNA1C-012
 
CACNA1C-013
 
CACNA1C-015
 
CACNA1C-017
 
CACNA1C-018
 
CACNA1C-019
 
CACNA1C-020
 
CACNA1C-021
 
CACNA1C-022
 
CACNA1C-023
 
CACNA1C-024
 
CACNA1C-031
 
CACNA1C-032
 
CACNA1C-034
 
 » 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CACNA1C-001 ENSP00000382563
ENST00000399655
Q13936
Show all »
Show » Show » 2138 239.6 No >9
CACNA1C-002 ENSP00000382504
ENST00000399595
Q13936
Show all »
Show » Show » 2146 240.4 No >9
CACNA1C-003 ENSP00000382552
ENST00000399644
Q13936
Show all »
Show » Show » 2138 239.5 No >9
CACNA1C-004 ENSP00000382547
ENST00000399638
Q13936
Show all »
Show » Show » 2166 242.8 No >9
CACNA1C-005 ENSP00000382506
ENST00000399597
Q13936
Show all »
Show » Show » 2138 239.7 No >9
CACNA1C-006 ENSP00000382530
ENST00000399621
Q13936
Show all »
Show » Show » 2157 241.6 No >9
CACNA1C-007 ENSP00000382546
ENST00000399637
Q13936
Show all »
Show » Show » 2157 241.5 No >9
CACNA1C-008 ENSP00000382500
ENST00000399591
Q13936
Show all »
Show » Show » 2146 240.3 No >9
CACNA1C-010 ENSP00000382549
ENST00000399641
Q13936
Show all »
Show » Show » 2138 239.5 No >9
CACNA1C-011 ENSP00000382512
ENST00000399603
E9PDJ1
Show all »
Show » Show » 2138 239.7 No >9
CACNA1C-012 ENSP00000382542
ENST00000399634
E9PDI6
Show all »
Show » Show » 2209 247.1 No >9
CACNA1C-013 ENSP00000382526
ENST00000399617
Q13936
Show all »
Show » Show » 2173 243.6 No >9
CACNA1C-015 ENSP00000336982
ENST00000335762
F5H522
Show all »
Show » Show » 2163 242.4 No >9
CACNA1C-017 ENSP00000266376
ENST00000347598
Q13936
Show all »
Show » Show » 2186 245 No >9
CACNA1C-018 ENSP00000437936
ENST00000480911
F5H638
Show all »
Show » Show » 1279 144.7 No >9
CACNA1C-019 ENSP00000382515
ENST00000399606
Q13936
Show all »
Show » Show » 2158 241.9 No >9
CACNA1C-020 ENSP00000382510
ENST00000399601
Q13936
Show all »
Show » Show » 2138 239.5 No >9
CACNA1C-021 ENSP00000341092
ENST00000344100
Q13936
Show all »
Show » Show » 2179 243.7 No >9
CACNA1C-022 ENSP00000382537
ENST00000399629
Q13936
Show all »
Show » Show » 2155 241.5 No >9
CACNA1C-023 ENSP00000329877
ENST00000327702
Q13936
Show all »
Show » Show » 2173 243.4 No >9
CACNA1C-024 ENSP00000382557
ENST00000399649
Q13936
Show all »
Show » Show » 2144 240.2 No >9
CACNA1C-031 ENSP00000385896
ENST00000406454
F5GY28
Show all »
Show » Show » 2209 247.2 No >9
CACNA1C-032 ENSP00000385724
ENST00000402845
Q13936
Show all »
Show » Show » 2157 241.6 No >9
CACNA1C-034 ENSP00000445849
ENST00000543114
F5H0X0
Show all »
Show » 100 10.4 No 0