ADAMTS12

GENE INFORMATION

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Gene name

ADAMTS12

Synonyms

Description

ADAM metallopeptidase with thrombospondin type 1 motif, 12 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS-1) motif. Individual members of this family differ in the number of C-terminal TS-1 motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains eight TS-1 motifs. It may play roles in pulmonary cells during fetal development or in tumor processes through its proteolytic activity or as a molecule potentially involved in regulation of cell adhesion. [provided by RefSeq, Jul 2008]

Chromosome

5 (Chromosome progress)

Cytoband

p13.2

Chromosome location (bp)

33523640 - 33892297

Ensembl

ENSG00000151388 (version 73.37)

Entrez gene

81792

UniProt

P58397 (UniProt - Evidence at protein level)

neXtProt

NX_P58397

Antibodypedia

ADAMTS12 antibodies
 

PROTEIN VIEW

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ADAMTS12-001
 
ADAMTS12-002
 
ADAMTS12-003
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ADAMTS12-001 ENSP00000344847
ENST00000352040
P58397
Show all »
Show » Show » 1509 168.5 Yes 0
ADAMTS12-002 ENSP00000422554
ENST00000504830
P58397
Show all »
Show » Show » 1594 177.7 Yes 0
ADAMTS12-003 ENSP00000421638
ENST00000515401
D6REX0
Show all »
Show » 232 26.4 Yes 0