PTPRO

GENE INFORMATION

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Gene name

PTPRO (HGNC Symbol)

Synonyms

GLEPP1, NPHS6, PTP-oc, PTP-U2, PTPU2

Description

protein tyrosine phosphatase, receptor type, O (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the R3 subtype family of receptor-type protein tyrosine phosphatases. These proteins are localized to the apical surface of polarized cells and may have tissue-specific functions through activation of Src family kinases. This gene contains two distinct promoters, and alternatively spliced transcript variants encoding multiple isoforms have been observed. The encoded proteins may have multiple isoform-specific and tissue-specific functions, including the regulation of osteoclast production and activity, inhibition of cell proliferation and facilitation of apoptosis. This gene is a candidate tumor suppressor, and decreased expression of this gene has been observed in several types of cancer. [provided by RefSeq, May 2011]

Chromosome

12 (Chromosome progress)

Cytoband

p12.3

Chromosome location (bp)

15475331 - 15750333

Ensembl

ENSG00000151490 (version 73.37)

Entrez gene

5800

UniProt

Q16827 (UniProt - Evidence at protein level)

neXtProt

NX_Q16827

Antibodypedia

PTPRO antibodies
 

PROTEIN VIEW

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PTPRO-001
 
PTPRO-002
 
PTPRO-003
 
PTPRO-004
 
PTPRO-005
 
PTPRO-006
 
PTPRO-007
 
PTPRO-011
 
PTPRO-012
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PTPRO-001 ENSP00000281171
ENST00000281171
Q16827
Show all »
Show » Show » 1216 138.3 Yes 2
PTPRO-002 ENSP00000343434
ENST00000348962
Q16827
Show all »
Show » Show » 1188 134.9 Yes 2
PTPRO-003 ENSP00000444173
ENST00000543886
Q8IYG3
Show all »
Show » Show » 597 67.7 Yes 0
PTPRO-004 ENSP00000404188
ENST00000442921
Q16827
Show all »
Show » Show » 405 47.2 No 2
PTPRO-005 ENSP00000437571
ENST00000542557
Q16827
Show all »
Show » Show » 377 43.8 No 1
PTPRO-006 ENSP00000393449
ENST00000445537
Q16827
Show all »
Show » Show » 405 47.2 No 2
PTPRO-007 ENSP00000439234
ENST00000544244
Q16827
Show all »
Show » Show » 377 43.8 No 1
PTPRO-011 ENSP00000445621
ENST00000535311
Show » 88 9.3 No 0
PTPRO-012 ENSP00000446201
ENST00000535322
H0YH60
Show all »
Show » 116 13.8 No 0