EPS8

GENERAL INFORMATION

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Gene name

EPS8

Gene description

Epidermal growth factor receptor pathway substrate 8

Protein class

Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

10
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Mixed
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

General cytoplasmic expression.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Data reliability

Uncertain based on 1 antibody.
HPA003897
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Mixed

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

EPS8

Synonyms

Description

Epidermal growth factor receptor pathway substrate 8 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the EPS8 family. This protein contains one PH domain and one SH3 domain. It functions as part of the EGFR pathway, though its exact role has not been determined. Highly similar proteins in other organisms are involved in the transduction of signals from Ras to Rac and growth factor-mediated actin remodeling. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]

Chromosome

12

Cytoband

p12.3

Chromosome location (bp)

15620158 - 15882329

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000151491 (version 78.38)

Entrez gene

2059

UniProt

Q12929 (UniProt - Evidence at protein level)

neXtProt

NX_Q12929

Antibodypedia

EPS8 antibodies


PROTEIN BROWSER

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ENST00000281172
 
ENST00000535752
 
ENST00000536793
 
ENST00000540613
 
ENST00000542903
 
ENST00000543363
 
ENST00000543523
 
ENST00000543612
 
ENST00000544064
 
ENST00000546311
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

EPS8-001 ENSP00000281172
ENST00000281172
Q12929
Show all »
Show » Show » 822 91.9 No 0
EPS8-003 ENSP00000441867
ENST00000543523
Q12929
Show all »
Show » Show » 822 91.9 No 0
EPS8-004 ENSP00000442388
ENST00000543612
Q12929
Show all »
Show » Show » 822 91.9 No 0
EPS8-005 ENSP00000441888
ENST00000540613
Q12929
Show all »
Show » Show » 562 62.9 No 0
EPS8-006 ENSP00000437806
ENST00000542903
Q12929
Show all »
Show » Show » 562 62.9 No 0
EPS8-007 ENSP00000444613
ENST00000543363
F5H2B8
Show all »
Show » 68 7.6 No 0
EPS8-008 ENSP00000445235
ENST00000546311
F5H3Q6
Show all »
Show » Show » 128 14.5 No 0
EPS8-009 ENSP00000438668
ENST00000536793
F5H2B8
Show all »
Show » 68 7.6 No 0
EPS8-010 ENSP00000445815
ENST00000544064
F5H1B5
Show all »
Show » 67 7.5 No 0
EPS8-017 ENSP00000440591
ENST00000535752
F5GYM8
Show all »
Show » Show » 121 13.6 No 0