DRD3

GENE INFORMATION

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Gene name

DRD3

Synonyms

Description

dopamine receptor D3 (HGNC Symbol)

Entrez gene summary

This gene encodes the D3 subtype of the five (D1-D5) dopamine receptors. The activity of the D3 subtype receptor is mediated by G proteins which inhibit adenylyl cyclase. This receptor is localized to the limbic areas of the brain, which are associated with cognitive, emotional, and endocrine functions. Genetic variation in this gene may be associated with susceptibility to hereditary essential tremor 1. Alternative splicing of this gene results in transcript variants encoding different isoforms, although some variants may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Jul 2008]

Chromosome

3 (Chromosome progress)

Cytoband

q13.31

Chromosome location (bp)

113847499 - 113918254

Ensembl

ENSG00000151577 (version 73.37)

Entrez gene

1814

UniProt

P35462 (UniProt - Evidence at protein level)

neXtProt

NX_P35462

Antibodypedia

DRD3 antibodies
 

PROTEIN VIEW

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DRD3-001
 
DRD3-002
 
DRD3-201
 
DRD3-202
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DRD3-001 ENSP00000419402
ENST00000460779
P35462
Show all »
Show » Show » 400 44.2 No 7
DRD3-002 ENSP00000420662
ENST00000467632
P35462
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Show » Show » 400 44.2 No 7
DRD3-201 ENSP00000295881
ENST00000295881
E9PCM4
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Show » Show » 367 40.7 No 7
DRD3-202 ENSP00000373169
ENST00000383673
P35462
Show all »
Show » Show » 400 44.2 No 7