AKR1C2

GENE INFORMATION

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Gene name

AKR1C2 (HGNC Symbol)

Synonyms

BABP, DD, DD2, DDH2, HAKRD, MCDR2

Description

aldo-keto reductase family 1, member C2 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols using NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme binds bile acid with high affinity, and shows minimal 3-alpha-hydroxysteroid dehydrogenase activity. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Chromosome

10 (Chromosome progress)

Cytoband

p15.1

Chromosome location (bp)

5029967 - 5060223

Ensembl

ENSG00000151632 (version 73.37)

Entrez gene

1646

UniProt

P52895 (UniProt - Evidence at protein level)

neXtProt

NX_P52895

Antibodypedia

AKR1C2 antibodies
 

PROTEIN VIEW

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AKR1C2-001
 
AKR1C2-003
 
AKR1C2-007
 
AKR1C2-201
 
AKR1C2-202
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

AKR1C2-001 ENSP00000370129
ENST00000380753
P52895
Show all »
Show » Show » 323 36.7 No 0
AKR1C2-003 ENSP00000392694
ENST00000421196
B4DK69
Show all »
Show » 297 33.8 No 0
AKR1C2-007 ENSP00000474566
ENST00000604507
200 22.6 No 0
AKR1C2-201 ENSP00000385221
ENST00000407674
P52895
Show all »
Show » Show » 323 36.7 No 0
AKR1C2-202 ENSP00000408440
ENST00000455190
P52895
Show all »
Show » Show » 139 15.7 No 0