ASAP2

GENERAL INFORMATION

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Gene name

ASAP2

Gene description

ArfGAP with SH3 domain, ankyrin repeat and PH domain 2

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Mixed
GTEx:Tissue enhanced (testis)

Protein evidence

Evidence at protein level

Protein localization

Most normal tissues showed moderate to strong cytoplasmic staining combined with a few cases of nuclear positivity. Hepatocytes, mesenchymal cells and myocytes were weakly stained or negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
CAB018615
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Mixed

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (testis)

Organ

Expression



GENE INFORMATION

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Gene name

ASAP2 (HGNC Symbol)

Synonyms

CENTB3, DDEF2, KIAA0400, PAP, SHAG1

Description

ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a multidomain protein containing an N-terminal alpha-helical region with a coiled-coil motif, followed by a pleckstrin homology (PH) domain, an Arf-GAP domain, an ankyrin homology region, a proline-rich region, and a C-terminal Src homology 3 (SH3) domain. The protein localizes in the Golgi apparatus and at the plasma membrane, where it colocalizes with protein tyrosine kinase 2-beta (PYK2). The encoded protein forms a stable complex with PYK2 in vivo. This interaction appears to be mediated by binding of its SH3 domain to the C-terminal proline-rich domain of PYK2. The encoded protein is tyrosine phosphorylated by activated PYK2. It has catalytic activity for class I and II ArfGAPs in vitro, and can bind the class III Arf ARF6 without immediate GAP activity. The encoded protein is believed to function as an ARF GAP that controls ARF-mediated vesicle budding when recruited to Golgi membranes. In addition, it functions as a substrate and downstream target for PYK2 and SRC, a pathway that may be involved in the regulation of vesicular transport. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

Chromosome

2

Cytoband

p25.1

Chromosome location (bp)

9206765 - 9405683

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000151693 (version 78.38)

Entrez gene

8853

UniProt

O43150 (UniProt - Evidence at protein level)

neXtProt

NX_O43150

Antibodypedia

ASAP2 antibodies


PROTEIN BROWSER

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ENST00000281419
 
ENST00000315273
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ASAP2-001 ENSP00000281419
ENST00000281419
O43150
Show all »
Show » Show » 1006 111.7 No 0
ASAP2-201 ENSP00000316404
ENST00000315273
O43150
Show all »
Show » Show » 961 107 No 0