ASAP2

GENE INFORMATION

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Gene name

ASAP2 (HGNC Symbol)

Synonyms

CENTB3, DDEF2, KIAA0400, PAP, SHAG1

Description

ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a multidomain protein containing an N-terminal alpha-helical region with a coiled-coil motif, followed by a pleckstrin homology (PH) domain, an Arf-GAP domain, an ankyrin homology region, a proline-rich region, and a C-terminal Src homology 3 (SH3) domain. The protein localizes in the Golgi apparatus and at the plasma membrane, where it colocalizes with protein tyrosine kinase 2-beta (PYK2). The encoded protein forms a stable complex with PYK2 in vivo. This interaction appears to be mediated by binding of its SH3 domain to the C-terminal proline-rich domain of PYK2. The encoded protein is tyrosine phosphorylated by activated PYK2. It has catalytic activity for class I and II ArfGAPs in vitro, and can bind the class III Arf ARF6 without immediate GAP activity. The encoded protein is believed to function as an ARF GAP that controls ARF-mediated vesicle budding when recruited to Golgi membranes. In addition, it functions as a substrate and downstream target for PYK2 and SRC, a pathway that may be involved in the regulation of vesicular transport. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

Chromosome

2 (Chromosome progress)

Cytoband

p25.1

Chromosome location (bp)

9346894 - 9545812

Ensembl

ENSG00000151693 (version 73.37)

Entrez gene

8853

UniProt

O43150 (UniProt - Evidence at protein level)

neXtProt

NX_O43150

Antibodypedia

ASAP2 antibodies
 

PROTEIN VIEW

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ASAP2-001
 
ASAP2-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ASAP2-001 ENSP00000281419
ENST00000281419
O43150
Show all »
Show » Show » 1006 111.7 No 0
ASAP2-201 ENSP00000316404
ENST00000315273
O43150
Show all »
Show » Show » 961 107 No 0