ADAM17

GENE INFORMATION

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Gene name

ADAM17 (HGNC Symbol)

Synonyms

CD156B, cSVP, TACE

Description

ADAM metallopeptidase domain 17 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene functions as a tumor necrosis factor-alpha converting enzyme; binds mitotic arrest deficient 2 protein; and also plays a prominent role in the activation of the Notch signaling pathway. [provided by RefSeq, Jul 2008]

Chromosome

2 (Chromosome progress)

Cytoband

p25.1

Chromosome location (bp)

9628615 - 9695921

Ensembl

ENSG00000151694 (version 73.37)

Entrez gene

6868

UniProt

P78536 (UniProt - Evidence at protein level)

neXtProt

NX_P78536

Antibodypedia

ADAM17 antibodies
 

PROTEIN VIEW

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ADAM17-001
 
ADAM17-003
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ADAM17-001 ENSP00000309968
ENST00000310823
P78536
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Show » Show » 824 93 Yes 1
ADAM17-003 ENSP00000418728
ENST00000497134
E7EUI5
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Show » 285 33.2 Yes 0