ACSL1

GENERAL INFORMATION

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Gene name

ACSL1

Gene description

Acyl-CoA synthetase long-chain family member 1

Protein class

Enzymes
Mitochondrial proteins
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

Intracellular,Membrane

Number of transcripts

10
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic expression in most tissues except in CNS. High expression in adipocytes, liver, kidney, heart and skeletal muscle.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Data reliability

Uncertain based on 2 antibodies.
HPA011316 , HPA011964
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Soft tissue



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

ACSL1 (HGNC Symbol)

Synonyms

ACS1, FACL1, FACL2, LACS, LACS1, LACS2

Description

Acyl-CoA synthetase long-chain family member 1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]

Chromosome

4

Cytoband

q35.1

Chromosome location (bp)

184755595 - 184826818

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000151726 (version 78.38)

Entrez gene

2180

UniProt

P33121 (UniProt - Evidence at protein level)

neXtProt

NX_P33121

Antibodypedia

ACSL1 antibodies


PROTEIN BROWSER

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ENST00000281455
 
ENST00000454703
 
ENST00000503407
 
ENST00000504342
 
ENST00000504900
 
ENST00000505492
 
ENST00000507295
 
ENST00000513317
 
ENST00000515030
 
ENST00000622937
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ACSL1-001 ENSP00000281455
ENST00000281455
P33121
Show all »
Show » Show » 698 77.9 No 2
ACSL1-002 ENSP00000425006
ENST00000504342
P33121
Show all »
Show » Show » 698 77.9 No 2
ACSL1-004 ENSP00000424935
ENST00000504900
D6RER0
Show all »
Show » Show » 388 43.4 No 2
ACSL1-005 ENSP00000407165
ENST00000454703
B7Z3Z9
Show all »
Show » Show » 527 58.6 No 0
ACSL1-006 ENSP00000426244
ENST00000507295
E7EPM6
Show all »
Show » Show » 664 74.3 No 2
ACSL1-007 ENSP00000426150
ENST00000513317
P33121
Show all »
Show » Show » 698 77.9 No 2
ACSL1-008 ENSP00000425640
ENST00000505492
Q108N2
Show all »
Show » Show » 94 10.1 No 0
ACSL1-009 ENSP00000425098
ENST00000503407
H0Y9U7
Show all »
Show » Show » 294 32.8 No 0
ACSL1-011 ENSP00000422607
ENST00000515030
P33121
Show all »
Show » Show » 698 77.9 No 2
ACSL1-201 ENSP00000485264
ENST00000622937
B7Z3Z9
Show all »
Show » Show » 527 58.6 No 0