GRID2

GENERAL INFORMATION

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Gene name

GRID2

Gene description

Glutamate receptor, ionotropic, delta 2

Protein class

Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

Intracellular,Membrane

Number of transcripts

4
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enriched (testis)
GTEx:Group enriched (cerebellum, testis)

Protein evidence

Evidence at protein level

Protein localization

Expression in neuropil of cerebellum and subset of cells in seminiferous ducts.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded. RNA data for cerebellum not available for correlation.

Data reliability

Uncertain based on 2 antibodies.
HPA056253 , HPA058538
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Cerebellum

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enriched (testis)

Organ

Expression

GTEx dataset
RNA tissue category:  Group enriched (cerebellum, testis)

Organ

Expression



GENE INFORMATION

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Gene name

GRID2 (HGNC Symbol)

Synonyms

GluD2, GluR-delta-2

Description

Glutamate receptor, ionotropic, delta 2 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the family of ionotropic glutamate receptors which are the predominant excitatory neurotransmitter receptors in the mammalian brain. The encoded protein is a multi-pass membrane protein that is expressed selectively in cerebellar Purkinje cells. A point mutation in the mouse ortholog, associated with the phenotype named 'lurcher', in the heterozygous state leads to ataxia resulting from selective, cell-autonomous apoptosis of cerebellar Purkinje cells during postnatal development. Mice homozygous for this mutation die shortly after birth from massive loss of mid- and hindbrain neurons during late embryogenesis. This protein also plays a role in synapse organization between parallel fibers and Purkinje cells. Alternate splicing results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause cerebellar ataxia in humans. [provided by RefSeq, Apr 2014]

Chromosome

4

Cytoband

Chromosome location (bp)

92304399 - 93774556

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000152208 (version 78.38)

Entrez gene

2895

UniProt

O43424 (UniProt - Evidence at transcript level)

neXtProt

NX_O43424

Antibodypedia

GRID2 antibodies


PROTEIN BROWSER

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ENST00000282020
 
ENST00000510992
 
ENST00000512631
 
ENST00000611049
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GRID2-001 ENSP00000282020
ENST00000282020
O43424
Show all »
Show » Show » 1007 113.4 Yes 3
GRID2-002 ENSP00000421257
ENST00000510992
O43424
Show all »
Show » Show » 912 102.8 Yes 3
GRID2-005 ENSP00000423331
ENST00000512631
D6R976
Show all »
Show » 73 8.1 No 0
GRID2-201 ENSP00000483084
ENST00000611049
Q4W5F4
Show all »
Show » Show » 926 104.2 No 3