PDK1

GENE INFORMATION

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Gene name

PDK1

Synonyms

Description

pyruvate dehydrogenase kinase, isozyme 1 (HGNC Symbol)

Entrez gene summary

Pyruvate dehydrogenase (PDH) is a mitochondrial multienzyme complex that catalyzes the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. The enzymatic activity is regulated by a phosphorylation/dephosphorylation cycle. Phosphorylation of PDH by a specific pyruvate dehydrogenase kinase (PDK) results in inactivation. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2013]

Chromosome

2 (Chromosome progress)

Cytoband

q31.1

Chromosome location (bp)

173420101 - 173489823

Ensembl

ENSG00000152256 (version 73.37)

Entrez gene

5163

UniProt

Q15118 (UniProt - Evidence at protein level)

neXtProt

NX_Q15118

Antibodypedia

PDK1 antibodies
 

PROTEIN VIEW

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PDK1-001
 
PDK1-002
 
PDK1-003
 
PDK1-004
 
PDK1-005
 
PDK1-006
 
PDK1-007
 
PDK1-008
 
PDK1-201
 
PDK1-202
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PDK1-001 ENSP00000282077
ENST00000282077
Q15118
Show all »
Show » Show » 436 49.2 No 0
PDK1-002 ENSP00000386985
ENST00000410055
Q15118
Show all »
Show » Show » 436 49.2 No 0
PDK1-003 ENSP00000376352
ENST00000392571
E9PD65
Show all »
Show » Show » 456 51.6 No 0
PDK1-004 ENSP00000399558
ENST00000443353
C9JKT3
Show all »
Show » 154 17.8 No 0
PDK1-005 ENSP00000406608
ENST00000436490
F8WC75
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62 7.3 No 0
PDK1-006 ENSP00000413629
ENST00000431718
F8WEJ6
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164 18.5 No 0
PDK1-007 ENSP00000388366
ENST00000439519
C9JKT3
Show all »
Show » 154 17.8 No 0
PDK1-008 ENSP00000399160
ENST00000416991
C9IYB4
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Show » 229 26.3 No 0
PDK1-201 ENSP00000438567
ENST00000543905
B7Z7N6
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Show » 360 41.3 No 0
PDK1-202 ENSP00000437502
ENST00000544863
B7Z207
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Show » 281 32 No 0