ACMSD

GENE INFORMATION

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Gene name

ACMSD

Synonyms

Description

aminocarboxymuconate semialdehyde decarboxylase (HGNC Symbol)

Entrez gene summary

The neuronal excitotoxin quinolinate is an intermediate in the de novo synthesis pathway of NAD from tryptophan, and has been implicated in the pathogenesis of several neurodegenerative disorders. Quinolinate is derived from alpha-amino-beta-carboxy-muconate-epsilon-semialdehyde (ACMS). ACMSD (ACMS decarboxylase; EC 4.1.1.45) can divert ACMS to a benign catabolite and thus prevent the accumulation of quinolinate from ACMS.[supplied by OMIM, Oct 2004]

Chromosome

2 (Chromosome progress)

Cytoband

q21.3

Chromosome location (bp)

135596117 - 135659604

Ensembl

ENSG00000153086 (version 73.37)

Entrez gene

130013

UniProt

Q8TDX5 (UniProt - Evidence at protein level)

neXtProt

NX_Q8TDX5

Antibodypedia

ACMSD antibodies
 

PROTEIN VIEW

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ACMSD-001
 
ACMSD-002
 
ACMSD-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ACMSD-001 ENSP00000348459
ENST00000356140
Q8TDX5
Show all »
Show » Show » 336 38 No 0
ACMSD-002 ENSP00000376659
ENST00000392928
Q8TDX5
Show all »
Show » Show » 278 31.2 No 0
ACMSD-201 ENSP00000283054
ENST00000283054
Q8TDX5
Show all »
Show » Show » 278 31.2 No 0