Fields »

GENE INFORMATION

? »

Gene name

SLC25A27 (HGNC Symbol)

Synonyms

FLJ33552, UCP4

Description

solute carrier family 25, member 27 (HGNC Symbol)

Entrez gene summary

Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. Transcripts of this gene are only detected in brain tissue and are specifically modulated by various environmental conditions. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2011]

Chromosome

6 (Chromosome progress)

Cytoband

p12.3

Chromosome location (bp)

46620678 - 46649356

Ensembl

ENSG00000153291 (version 69.37)

Entrez gene

9481

UniProt

O95847

neXtProt

NX_O95847

Antibodypedia

SLC25A27 antibodies
 

PROTEIN VIEW

? »
 
 
 
SLC25A27-001
 
SLC25A27-002
 
SLC25A27-003
 
SLC25A27-004
 
SLC25A27-005
 
SLC25A27-201
 
SLC25A27-202
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SLC25A27-001 ENSP00000360398
ENST00000371347
O95847
Show all »
Show » Show » 323 36.1 No 0
SLC25A27-002 ENSP00000408120
ENST00000437459
Q5VTS5
Show all »
Show » 145 15.9 No 0
SLC25A27-003 ENSP00000396450
ENST00000444329
Q5VTS6
Show all »
Show » Show » 159 17.4 No 0
SLC25A27-004 ENSP00000391223
ENST00000425120
Q5VTS8
Show all »
Show » Show » 149 17 No 0
SLC25A27-005 ENSP00000402082
ENST00000417490
Q5VTS5
Show all »
Show » 98 10.7 No 0
SLC25A27-201 ENSP00000412024
ENST00000411689
F5GWR4
Show all »
Show » Show » 245 27.2 No 0
SLC25A27-202 ENSP00000412223
ENST00000452689
B4DZG4
Show all »
Show » Show » 237 26.7 No 0