GRAP

GENE INFORMATION

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Gene name

GRAP

Synonyms

Description

GRB2-related adaptor protein (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the GRB2/Sem5/Drk family and functions as a cytoplasmic signaling protein which contains an SH2 domain flanked by two SH3 domains. The SH2 domain interacts with ligand-activated receptors for stem cell factor and erythropoietin, and facilitates the formation of a stable complex with the BCR-ABL oncoprotein. This protein also associates with the Ras guanine nucleotide exchange factor SOS1 (son of sevenless homolog 1) through its N-terminal SH3 domain. In general, it couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway. [provided by RefSeq, Jul 2012]

Chromosome

17

Cytoband

p11.2

Chromosome location (bp)

18923986 - 18950950

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000154016 (version 75.37)

Entrez gene

10750

UniProt

Q13588 (UniProt - Evidence at protein level)

neXtProt

NX_Q13588

Antibodypedia

GRAP antibodies
 

PROTEIN VIEW

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GRAP-001
 
GRAP-002
 
GRAP-003
 
GRAP-006
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GRAP-001 ENSP00000284154
ENST00000284154
Q13588
Show all »
Show » Show » 217 25.3 No 0
GRAP-002 ENSP00000378997
ENST00000395635
A8MW78
Show all »
Show » Show » 188 22.1 No 0
GRAP-003 ENSP00000459833
ENST00000573099
I3L2P9
Show all »
Show » Show » 205 22.1 No 0
GRAP-006 ENSP00000464328
ENST00000583020
J3QRP9
Show all »
Show » Show » 103 11.9 No 0