GRAP

GENERAL INFORMATION

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Gene name

GRAP

Gene description

GRB2-related adaptor protein

Protein class

Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

3
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (lymph node, spleen, tonsil)
GTEx:Tissue enhanced (spleen)

Protein evidence

Evidence at protein level

Protein localization

General cytoplasmic expression with a granular pattern in some tissues.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly not consistent with RNA expression data.

Data reliability

Uncertain based on 1 antibody.
HPA046595
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Prostate



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (lymph node, spleen, tonsil)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (spleen)

Organ

Expression



GENE INFORMATION

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Gene name

GRAP

Synonyms

Description

GRB2-related adaptor protein (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the GRB2/Sem5/Drk family and functions as a cytoplasmic signaling protein which contains an SH2 domain flanked by two SH3 domains. The SH2 domain interacts with ligand-activated receptors for stem cell factor and erythropoietin, and facilitates the formation of a stable complex with the BCR-ABL oncoprotein. This protein also associates with the Ras guanine nucleotide exchange factor SOS1 (son of sevenless homolog 1) through its N-terminal SH3 domain. In general, it couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway. [provided by RefSeq, Jul 2012]

Chromosome

17

Cytoband

p11.2

Chromosome location (bp)

19020673 - 19047637

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000154016 (version 78.38)

Entrez gene

10750

UniProt

Q13588 (UniProt - Evidence at protein level)

neXtProt

NX_Q13588

Antibodypedia

GRAP antibodies


PROTEIN BROWSER

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ENST00000284154
 
ENST00000395635
 
ENST00000573099
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GRAP-001 ENSP00000284154
ENST00000284154
Q13588
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Show » Show » 217 25.3 No 0
GRAP-002 ENSP00000378997
ENST00000395635
A8MW78
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Show » Show » 188 22.1 No 0
GRAP-003 ENSP00000459833
ENST00000573099
I3L2P9
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Show » Show » 205 22.1 No 0