ANGPT1

GENE INFORMATION

? »

Gene name

ANGPT1 (HGNC Symbol)

Synonyms

Ang1, KIAA0003

Description

angiopoietin 1 (HGNC Symbol)

Entrez gene summary

Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The protein encoded by this gene is a secreted glycoprotein that activates the receptor by inducing its tyrosine phosphorylation. It plays a critical role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme and inhibits endothelial permeability. The protein also contributes to blood vessel maturation and stability, and may be involved in early development of the heart. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Dec 2010]

Chromosome

8 (Chromosome progress)

Cytoband

q23.1

Chromosome location (bp)

108261721 - 108510283

Ensembl

ENSG00000154188 (version 73.37)

Entrez gene

284

UniProt

Q15389 (UniProt - Evidence at protein level)

neXtProt

NX_Q15389

Antibodypedia

ANGPT1 antibodies
 

PROTEIN VIEW

? »
 
 
 
ANGPT1-001
 
ANGPT1-002
 
ANGPT1-003
 
ANGPT1-006
 
ANGPT1-009
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ANGPT1-001 ENSP00000428340
ENST00000517746
Q15389
Show all »
Show » Show » 498 57.5 Yes 0
ANGPT1-002 ENSP00000430750
ENST00000520734
B4DTQ9
Show all »
Show » 298 34.3 No 0
ANGPT1-003 ENSP00000297450
ENST00000297450
Q15389
Show all »
Show » Show » 497 57.5 Yes 0
ANGPT1-006 ENSP00000428908
ENST00000520033
E5RFF4
Show all »
Show » 30 3.3 No 0
ANGPT1-009 ENSP00000429349
ENST00000520052
E7ERK4
Show all »
297 34.3 No 0