PRKCA

GENE INFORMATION

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Gene name

PRKCA (HGNC Symbol)

Synonyms

PKCA

Description

protein kinase C, alpha (HGNC Symbol)

Entrez gene summary

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes. [provided by RefSeq, Jul 2008]

Chromosome

17 (Chromosome progress)

Cytoband

q24.2

Chromosome location (bp)

64298754 - 64806861

Ensembl

ENSG00000154229 (version 73.37)

Entrez gene

5578

UniProt

P17252 (UniProt - Evidence at protein level)

neXtProt

NX_P17252

Antibodypedia

PRKCA antibodies
 

PROTEIN VIEW

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PRKCA-001
 
PRKCA-002
 
PRKCA-003
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PRKCA-001 ENSP00000462087
ENST00000578063
J3KRN5
Show all »
Show » 308 35.5 No 0
PRKCA-002 ENSP00000408695
ENST00000413366
P17252
Show all »
Show » Show » 672 76.7 No 0
PRKCA-003 ENSP00000284384
ENST00000284384
Show » 150 17.1 No 0