OBSCN

GENE INFORMATION

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Gene name

OBSCN (HGNC Symbol)

Synonyms

ARHGEF30, KIAA1556, KIAA1639, UNC89

Description

obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF (HGNC Symbol)

Entrez gene summary

The obscurin gene spans more than 150 kb, contains over 80 exons and encodes a protein of approximately 720 kDa. The encoded protein contains 68 Ig domains, 2 fibronectin domains, 1 calcium/calmodulin-binding domain, 1 RhoGEF domain with an associated PH domain, and 2 serine-threonine kinase domains. This protein belongs to the family of giant sacromeric signaling proteins that includes titin and nebulin, and may have a role in the organization of myofibrils during assembly and may mediate interactions between the sarcoplasmic reticulum and myofibrils. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Chromosome

1 (Chromosome progress)

Cytoband

q42.13

Chromosome location (bp)

228395831 - 228566577

Ensembl

ENSG00000154358 (version 73.37)

Entrez gene

84033

UniProt

Q5VST9 (UniProt - Evidence at protein level)

neXtProt

NX_Q5VST9

Antibodypedia

OBSCN antibodies
 

PROTEIN VIEW

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OBSCN-001
 
OBSCN-002
 
OBSCN-006
 
OBSCN-009
 
OBSCN-010
 
OBSCN-011
 
OBSCN-201
 
OBSCN-202
 
OBSCN-203
 
OBSCN-204
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

OBSCN-001 ENSP00000284548
ENST00000284548
Q5VST9
Show all »
Show » Show » 6620 721.5 No 0
OBSCN-002 ENSP00000355667
ENST00000366706
Show » 858 94.7 No 0
OBSCN-006 ENSP00000455500
ENST00000474237
68 7.2 No 0
OBSCN-009 ENSP00000455688
ENST00000483539
Show » 1566 172.1 No 0
OBSCN-010 ENSP00000388554
ENST00000441106
Show » Show » 2583 281.8 No 0
OBSCN-011 ENSP00000455507
ENST00000570156
H3BPX2
Show all »
Show » Show » 8923 973 No 0
OBSCN-201 ENSP00000352613
ENST00000359599
H7BY31
Show all »
Show » 2757 301.7 No 0
OBSCN-202 ENSP00000355668
ENST00000366707
A6NGQ3
Show all »
Show » Show » 5602 611 No 0
OBSCN-203 ENSP00000355670
ENST00000366709
F8W8T3
Show all »
Show » Show » 3739 407.6 No 0
OBSCN-204 ENSP00000409493
ENST00000422127
Q5VST9
Show all »
Show » Show » 7968 868.5 No 0