MMP21

GENERAL INFORMATION

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Gene name

MMP21

Gene description

Matrix metallopeptidase 21

Protein class

Enzymes
FDA approved drug targets
Predicted secreted proteins

Predicted localization

Secreted

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (ovary)
GTEx:Tissue enhanced (ovary)

Protein evidence

Evidence at protein level

Protein localization

Most normal tissues were negative. Strong cytoplasmic and membranous immunoreactivity was observed in a subset of renal tubules and tonsil squamous epithelium. Smooth muscle displayed moderate positivity.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA024429
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (ovary)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (ovary)

Organ

Expression



GENE INFORMATION

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Gene name

MMP21

Synonyms

Description

Matrix metallopeptidase 21 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the matrix metalloproteinase family. Proteins in this family are involved in the breakdown of extracellular matrix for both normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, and disease processes, such as asthma and tumor metastasis. The encoded protein may play an important role in embryogenesis, particularly in neuronal cells, as well as in lymphocyte development and survival. [provided by RefSeq, May 2013]

Chromosome

10

Cytoband

q26.2

Chromosome location (bp)

125766453 - 125775821

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000154485 (version 78.38)

Entrez gene

118856

UniProt

Q8N119 (UniProt - Evidence at transcript level)

neXtProt

NX_Q8N119

Antibodypedia

MMP21 antibodies


PROTEIN BROWSER

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ENST00000368808
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MMP21-001 ENSP00000357798
ENST00000368808
Q8N119
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