The primary data page shows the detailed antibody staining in 76 different cell types for each analyzed antibody. In addition, for each cell type, a knowledge-based annotated protein expression score based on all analyzed antibodies is displayed furthest to the right. The images and annotations can be accessed by clicking on the tissue name or score bar. More information can be found in Assays & Annotation.
The tissues and cell types can be ordered by organ, cell type or alphabetically. If ordered by organ, the tissues are presented in groups according to functional features. If ordered by cell type, the cells are presented in groups related to origin.
This score describes the level of antibody staining observed in the annotated cell types as not detected (n), low (l), medium (m) or high (h). It is based on the staining intensity and fraction of stained cells. The images and annotations can be accessed by clicking on the tissue name or score bar. More information can be found in Assays & Annotation.
This score describes a knowledge-based best estimate of the protein expression in the annotated cell types as not detected (n), low (l), medium (m) or high (h). It is a result of stringent evaluation of immunohistochemical staining pattern, RNA data from internal and external sources and available protein/gene characterization data. More information can be found in Assays & Annotation.
Summarizing texts describe the staining pattern for each antibody based on staining intensity, fraction of stained cells and subcellular localization. More information can be found in Assays & Annotation.
Strong cytoplasmic and membranous staining was observed in glands of Brunner, in urinary bladder and in stomach. Salivary gland and pancreas displayed strong cytoplasmic staining with a granular pattern. Remaining normal tissues were in general negative.
Distinct membranous staining often combined with weaker cytoplasmic positivity was observed in most normal tissues. Strong staining was for example observed in gastric glands, prostate, urothelium and seminiferous ducts. Subsets of cells in cerebral cortex showed distinct nuclear membranous positivity. Lymphoid tissues and smooth muscle cells were generally negative.
Most normal tissues showed distinct membranous staining and/or weak to moderate cytoplasmic positivity. The gastrointestinal tract, prostate, seminiferus duct cells and endometrial glandular cells showed strong membranous immunoreactivity. Alveolar cells, pancreatic islets, renal glomeruli, myocytes, cells in CNS and lymphoid tissues were weakly stained or negative.
Normal tissues showed weak to moderate cytoplasmic and often membranous staining.