JAM2

GENERAL INFORMATION

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Gene name

JAM2

Gene description

Junctional adhesion molecule 2

Protein class

CD markers
Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

3
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Mixed
GTEx:Expressed in all

Protein evidence

Evidence at protein level

ANTIBODY RELIABILITY

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Data reliability

Pending normal tissue annotation.
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Kidney & urinary bladder
N/A
Male tissues
N/A
Testis
N/A
Epididymis
N/A
N/A
Prostate
N/A
Seminal vesicle
N/A
N/A
Female tissues
N/A
Breast
N/A
N/A
Vagina
N/A
N/A
Cervix, uterine
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Skin
N/A
Skin
N/A


PROTEIN EXPRESSION OVERVIEW

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Pending normal tissue annotation.


RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Mixed

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

JAM2 (HGNC Symbol)

Synonyms

C21orf43, CD322, JAM-B, JAMB, VE-JAM

Description

Junctional adhesion molecule 2 (HGNC Symbol)

Entrez gene summary

This gene belongs to the immunoglobulin superfamily, and the junctional adhesion molecule (JAM) family. The protein encoded by this gene is a type I membrane protein that is localized at the tight junctions of both epithelial and endothelial cells. It acts as an adhesive ligand for interacting with a variety of immune cell types, and may play a role in lymphocyte homing to secondary lymphoid organs. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2012]

Chromosome

21

Cytoband

q21.3

Chromosome location (bp)

25639272 - 25717562

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000154721 (version 78.38)

Entrez gene

58494

UniProt

P57087 (UniProt - Evidence at protein level)

neXtProt

NX_P57087

Antibodypedia

JAM2 antibodies


PROTEIN BROWSER

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ENST00000312957
 
ENST00000400532
 
ENST00000480456
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

JAM2-001 ENSP00000420419
ENST00000480456
P57087
Show all »
Show » Show » 298 33.2 Yes 1
JAM2-003 ENSP00000383376
ENST00000400532
P57087
Show all »
Show » Show » 312 34.6 Yes 1
JAM2-201 ENSP00000318416
ENST00000312957
P57087
Show all »
Show » Show » 262 29 Yes 1