GABPA

GENE INFORMATION

? »

Gene name

GABPA (HGNC Symbol)

Synonyms

E4TF1-60, E4TF1A, NFT2, NRF2, NRF2A

Description

GA binding protein transcription factor, alpha subunit 60kDa (HGNC Symbol)

Entrez gene summary

This gene encodes one of three GA-binding protein transcription factor subunits which functions as a DNA-binding subunit. Since this subunit shares identity with a subunit encoding the nuclear respiratory factor 2 gene, it is likely involved in activation of cytochrome oxidase expression and nuclear control of mitochondrial function. This subunit also shares identity with a subunit constituting the transcription factor E4TF1, responsible for expression of the adenovirus E4 gene. Because of its chromosomal localization and ability to form heterodimers with other polypeptides, this gene may play a role in the Down Syndrome phenotype. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Oct 2010]

Chromosome

21 (Chromosome progress)

Cytoband

q21.3

Chromosome location (bp)

27106881 - 27144771

Ensembl

ENSG00000154727 (version 73.37)

Entrez gene

2551

UniProt

Q06546 (UniProt - Evidence at protein level)

neXtProt

NX_Q06546

Antibodypedia

GABPA antibodies
 

PROTEIN VIEW

? »
 
 
 
GABPA-001
 
GABPA-002
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GABPA-001 ENSP00000382948
ENST00000400075
Q06546
Show all »
Show » Show » 454 51.3 No 0
GABPA-002 ENSP00000346886
ENST00000354828
Q06546
Show all »
Show » Show » 454 51.3 No 0