ADAMTS1

GENE INFORMATION

? »

Gene name

ADAMTS1 (HGNC Symbol)

Synonyms

C3-C5, KIAA1346, METH1

Description

ADAM metallopeptidase with thrombospondin type 1 motif, 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene contains two disintegrin loops and three C-terminal TS motifs and has anti-angiogenic activity. The expression of this gene may be associated with various inflammatory processes as well as development of cancer cachexia. This gene is likely to be necessary for normal growth, fertility, and organ morphology and function. [provided by RefSeq, Jul 2008]

Chromosome

21 (Chromosome progress)

Cytoband

q21.3

Chromosome location (bp)

28208606 - 28217728

Ensembl

ENSG00000154734 (version 73.37)

Entrez gene

9510

UniProt

Q9UHI8 (UniProt - Evidence at protein level)

neXtProt

NX_Q9UHI8

Antibodypedia

ADAMTS1 antibodies
 

PROTEIN VIEW

? »
 
 
 
ADAMTS1-001
 
ADAMTS1-003
 
ADAMTS1-006
 
ADAMTS1-007
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ADAMTS1-001 ENSP00000284984
ENST00000284984
Q9UHI8
Show all »
Show » Show » 967 105.4 Yes 0
ADAMTS1-003 ENSP00000403404
ENST00000451462
Show » Show » 200 22.3 No 1
ADAMTS1-006 ENSP00000431065
ENST00000517452
E5RJR7
Show all »
Show » 128 14.6 No 0
ADAMTS1-007 ENSP00000429557
ENST00000517777
E5RI60
Show all »
Show » 171 18.8 No 0