ADAMTS5

GENE INFORMATION

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Gene name

ADAMTS5 (HGNC Symbol)

Synonyms

ADAMTS11, ADMP-2

Description

ADAM metallopeptidase with thrombospondin type 1 motif, 5 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs and functions as aggrecanase to cleave aggrecan, a major proteoglycan of cartilage. [provided by RefSeq, Jul 2008]

Chromosome

21 (Chromosome progress)

Cytoband

q21.3

Chromosome location (bp)

28290231 - 28338832

Ensembl

ENSG00000154736 (version 73.37)

Entrez gene

11096

UniProt

Q9UNA0 (UniProt - Evidence at protein level)

neXtProt

NX_Q9UNA0

Antibodypedia

ADAMTS5 antibodies
 

PROTEIN VIEW

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ADAMTS5-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ADAMTS5-001 ENSP00000284987
ENST00000284987
Q9UNA0
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