PIEZO2

GENERAL INFORMATION

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Gene name

PIEZO2

Gene description

Piezo-type mechanosensitive ion channel component 2

Protein class

Disease related genes
Potential drug targets
Predicted intracellular proteins
Predicted membrane proteins
Transporters

Predicted localization

Intracellular,Membrane

Number of transcripts

9
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Mixed
GTEx:Mixed

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic expression in most tissues along with membranous positivity in several tissues.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 3 antibodies.
HPA015986 , HPA031974 , HPA040616
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Stomach

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Mixed

Organ

Expression

GTEx dataset
RNA tissue category:  Mixed

Organ

Expression



GENE INFORMATION

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Gene name

PIEZO2 (HGNC Symbol)

Synonyms

C18orf30, C18orf58, FAM38B, FAM38B2, FLJ23144, FLJ23403, FLJ34907, HsT748, HsT771

Description

Piezo-type mechanosensitive ion channel component 2 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene contains more than thirty transmembrane domains and likely functions as part of mechanically-activated (MA) cation channels. These channels serve to connect mechanical forces to biological signals. The encoded protein quickly adapts MA currents in somatosensory neurons. Defects in this gene are a cause of type 5 distal arthrogryposis. Several alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2014]

Chromosome

18

Cytoband

Chromosome location (bp)

10666483 - 11148762

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000154864 (version 78.38)

Entrez gene

63895

UniProt

Q9H5I5 (UniProt - Evidence at protein level)

neXtProt

NX_Q9H5I5

Antibodypedia

PIEZO2 antibodies


PROTEIN BROWSER

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ENST00000302079
 
ENST00000383408
 
ENST00000503781
 
ENST00000538948
 
ENST00000579112
 
ENST00000579949
 
ENST00000580640
 
ENST00000582937
 
ENST00000583325
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PIEZO2-003 ENSP00000421377
ENST00000503781
Q9H5I5
Show all »
Show » Show » 2752 318.1 Yes >9
PIEZO2-004 ENSP00000462560
ENST00000583325
J3KSM7
Show all »
Show » Show » 192 22.9 No 4
PIEZO2-005 ENSP00000477311
ENST00000579949
Show » 153 17.6 No 0
PIEZO2-006 ENSP00000463094
ENST00000580640
Q9H5I5
Show all »
Show » Show » 2777 320.9 Yes >9
PIEZO2-007 ENSP00000303316
ENST00000302079
Q9H5I5
Show all »
Show » Show » 2689 311.1 Yes >9
PIEZO2-010 ENSP00000462187
ENST00000582937
J3KRW1
Show all »
Show » 92 10.3 No 0
PIEZO2-011 ENSP00000443129
ENST00000538948
Q9H5I5
Show all »
Show » Show » 709 80.8 No 6
PIEZO2-013 ENSP00000463589
ENST00000579112
Show » 178 20.5 No 1
PIEZO2-201 ENSP00000372900
ENST00000383408
J3KSM7
Show all »
Show » Show » 2703 312.6 No >9