The primary data page shows the detailed antibody staining in 76 different cell types for each analyzed antibody. In addition, for each cell type, a knowledge-based annotated protein expression score based on all analyzed antibodies is displayed furthest to the right. The images and annotations can be accessed by clicking on the tissue name or score bar. More information can be found in Assays & Annotation.
The tissues and cell types can be ordered by organ, cell type or alphabetically. If ordered by organ, the tissues are presented in groups according to functional features. If ordered by cell type, the cells are presented in groups related to origin.
This score describes the level of antibody staining observed in the annotated cell types as not detected (n), low (l), medium (m) or high (h). It is based on the staining intensity and fraction of stained cells. The images and annotations can be accessed by clicking on the tissue name or score bar. More information can be found in Assays & Annotation.
This score describes a knowledge-based best estimate of the protein expression in the annotated cell types as not detected (n), low (l), medium (m) or high (h). It is a result of stringent evaluation of immunohistochemical staining pattern, RNA data from internal and external sources and available protein/gene characterization data. More information can be found in Assays & Annotation.
Summarizing texts describe the staining pattern for each antibody based on staining intensity, fraction of stained cells and subcellular localization. More information can be found in Assays & Annotation.
Normal tissues displayed moderate to strong cytoplasmic and/or nuclear staining. Breast and bile duct cells were weakly positive.
Normal tissues showed moderate to strong nuclear positivity. Additional membranous positivity was observed in respiratory epithelia, fallopian tube and epididymis.
Strong cytoplasmic staining was observed in lymphoid cells, epididymis, cilia of respiratory epithelium and fallopian tube. The intestine, adrenal cortex, renal tubules, decidual cells, smooth muscle cells and neuronal cells of CNS displayed moderate cytoplasmic immunoreactivity. Remaining normal tissues were weakly stained or negative.
Moderate cytoplasmic and membranous positivity with occasional nuclear staining was observed in normal tissues. Gall bladder, adrenal, upper respiratory epithelia, placenta, fallopian tube, urothelium and male genital tract were strongly stained.
Normal tissues displayed moderate to strong nuclear positivity. Additional membranous staining was observed in respiratory epithelia and fallopian tubes while exocrine pancreas showed additional cytoplasmic staining. Neuronal cells were weakly stained or negative.
Most normal tissues displayed moderate to strong cytoplasmic positivity. Ciliated cells of respiratory epithelia and fallopian tube were strongly stained. Alveolar macrophages, salivary gland, liver, adipocytes, hematopoietic cells, heart myocytes, germinal and non germinal center cells were generally negative.