ATP6V1C1

GENE INFORMATION

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Gene name

ATP6V1C1 (HGNC Symbol)

Synonyms

ATP6C, ATP6D, VATC, Vma5

Description

ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1 (HGNC Symbol)

Entrez gene summary

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene is one of two genes that encode the V1 domain C subunit proteins and is found ubiquitously. This C subunit is analogous but not homologous to gamma subunit of F-ATPases. Previously, this gene was designated ATP6D. [provided by RefSeq, Jul 2008]

Chromosome

8 (Chromosome progress)

Cytoband

q22.3

Chromosome location (bp)

104033291 - 104085279

Ensembl

ENSG00000155097 (version 73.37)

Entrez gene

528

UniProt

P21283 (UniProt - Evidence at protein level)

neXtProt

NX_P21283

Antibodypedia

ATP6V1C1 antibodies
 

PROTEIN VIEW

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ATP6V1C1-001
 
ATP6V1C1-002
 
ATP6V1C1-003
 
ATP6V1C1-004
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ATP6V1C1-001 ENSP00000379203
ENST00000395862
P21283
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Show » Show » 382 43.9 No 0
ATP6V1C1-002 ENSP00000428204
ENST00000518857
E7EV59
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Show » Show » 307 35.7 No 0
ATP6V1C1-003 ENSP00000430129
ENST00000521514
E7EV59
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Show » Show » 307 35.7 No 0
ATP6V1C1-004 ENSP00000430282
ENST00000518738
P21283
Show all »
Show » Show » 382 43.9 No 0