CDK19

GENERAL INFORMATION

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Gene name

CDK19

Gene description

Cyclin-dependent kinase 19

Protein class

Enzymes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

4
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Moderate nuclear and/or cytoplasmic staining was seen in the majority of normal tissues. Endothelial and smooth muscle cells displayed a distinct membranous/cytoplasmic positivity. Bile ducts in the liver were unstained.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA007053
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

CDK19 (HGNC Symbol)

Synonyms

bA346C16.3, CDC2L6, CDK11, KIAA1028

Description

Cyclin-dependent kinase 19 (HGNC Symbol)

Entrez gene summary

This gene encodes a protein that is one of the components of the Mediator co-activator complex. The Mediator complex is a multi-protein complex required for transcriptional activation by DNA binding transcription factors of genes transcribed by RNA polymerase II. The protein encoded by this gene is similar to cyclin-dependent kinase 8 which can also be a component of the Mediator complex. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]

Chromosome

6

Cytoband

q21

Chromosome location (bp)

110609978 - 110815958

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000155111 (version 78.38)

Entrez gene

23097

UniProt

Q9BWU1 (UniProt - Evidence at protein level)

neXtProt

NX_Q9BWU1

Antibodypedia

CDK19 antibodies


PROTEIN BROWSER

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ENST00000323817
 
ENST00000368911
 
ENST00000413605
 
ENST00000457688
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CDK19-001 ENSP00000357907
ENST00000368911
Q9BWU1
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Show » Show » 502 56.8 No 0
CDK19-002 ENSP00000317665
ENST00000323817
Q9BWU1
Show all »
Show » Show » 442 49.9 No 0
CDK19-003 ENSP00000415621
ENST00000457688
Q5JQZ9
Show all »
Show » Show » 251 29.4 No 0
CDK19-201 ENSP00000410604
ENST00000413605
Show » Show » 398 44.9 No 0