The cancer tissue page shows antibody staining in 20 different cancers. The overall cancer tissue staining statistics shows the fraction of patient samples with high, medium, low or not detected (as described by the color-coding scale in the box to the right), using all the available antibodies to the protein targets encoded by this gene. The assay and annotation is described here.
The cancers can be ordered histologically or alphabetically.
For each cancer, the staining for each available antibody is reported as the fraction of samples with antibody staining level high, medium, low or not detected (as described by the color-coding scale in the box to the right). The length of the bar represents the number of patient samples analyzed (max=12 patients).
By clicking on a cancer tissue, the detailed staining data for that cancer is available, including annotated images.
At the bottom of this page, a summary for the cancer staining for each antibody is given, together with the literature conformity for the staining pattern revealed by that specific antibody.
Cancer tissues displayed weak to moderate nuclear staining with additional cytoplasmic and membranous positivity in few tissues. Thyroid carcinomas along with rare case of lymphoma, lung, urothelial, pancreas and liver cancers were strongly stained. Several cases of melanomas, testicular and renal cancers were negative.
Cancer tissues showed weak to moderate cytoplasmic staining with additional nuclear positivity in several cases. Thyroid cancers displayed strong nuclear and cytoplasmic positivity. A majority of colorectal cancers along with a few cases of melanomas, liver, pancreas and lung cancers displayed strong cytoplasmic immunoreactivity.
Most cancer cells showed moderate to strong cytoplasmic with additional nuclear and/or membranous immunoreactivity in several cases. Several lymphomas, melanomas and prostate cancers were weakly stained or negative.
Consistent with gene/protein characterization data
Partly consistent with extensive gene/protein characterization data
No avaliable characterization data
Level of antibody staining/expression
High Medium Low Not detected
The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.