ADK

GENERAL INFORMATION

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Gene name

ADK

Gene description

Adenosine kinase

Protein class

Disease related genes
Enzymes
FDA approved drug targets
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

4
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

General cytoplasmic and nuclear expression.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Data reliability

Uncertain based on 3 antibodies.
HPA038391 , HPA038409 , CAB032876
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

ADK (HGNC Symbol)

Synonyms

AK

Description

Adenosine kinase (HGNC Symbol)

Entrez gene summary

This gene an enzyme which catalyzes the transfer of the gamma-phosphate from ATP to adenosine, thereby serving as a regulator of concentrations of both extracellular adenosine and intracellular adenine nucleotides. Adenosine has widespread effects on the cardiovascular, nervous, respiratory, and immune systems and inhibitors of the enzyme could play an important pharmacological role in increasing intravascular adenosine concentrations and acting as anti-inflammatory agents. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

Chromosome

10

Cytoband

q22.2

Chromosome location (bp)

74151185 - 74709303

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000156110 (version 78.38)

Entrez gene

132

UniProt

P55263 (UniProt - Evidence at protein level)

neXtProt

NX_P55263

Antibodypedia

ADK antibodies


PROTEIN BROWSER

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ENST00000286621
 
ENST00000372734
 
ENST00000539909
 
ENST00000541550
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ADK-001 ENSP00000286621
ENST00000286621
P55263
Show all »
Show » Show » 362 40.5 No 0
ADK-003 ENSP00000361819
ENST00000372734
P55263
Show all »
Show » Show » 345 38.7 No 0
ADK-201 ENSP00000443965
ENST00000539909
P55263
Show all »
Show » Show » 305 34.1 No 0
ADK-202 ENSP00000438321
ENST00000541550
P55263
Show all »
Show » Show » 327 36.6 No 0