The primary data page shows the detailed antibody staining in 76 different cell types for each analyzed antibody. In addition, for each cell type, a knowledge-based annotated protein expression score based on all analyzed antibodies is displayed furthest to the right. The images and annotations can be accessed by clicking on the tissue name or score bar. More information can be found in Assays & Annotation.
The tissues and cell types can be ordered by organ, cell type or alphabetically. If ordered by organ, the tissues are presented in groups according to functional features. If ordered by cell type, the cells are presented in groups related to origin.
This score describes the level of antibody staining observed in the annotated cell types as not detected (n), low (l), medium (m) or high (h). It is based on the staining intensity and fraction of stained cells. The images and annotations can be accessed by clicking on the tissue name or score bar. More information can be found in Assays & Annotation.
This score describes a knowledge-based best estimate of the protein expression in the annotated cell types as not detected (n), low (l), medium (m) or high (h). It is a result of stringent evaluation of immunohistochemical staining pattern, RNA data from internal and external sources and available protein/gene characterization data. More information can be found in Assays & Annotation.
Summarizing texts describe the staining pattern for each antibody based on staining intensity, fraction of stained cells and subcellular localization. More information can be found in Assays & Annotation.
Normal tissues displayed weak to moderate nuclear staining with additional cytoplasmic positivity in few tissues. Renal tubules, parathyroid, chondrocytes and islets of Langerhans were strongly stained. Hematopoietic cells, Purkinje cells, glial cells and bile ducts were negative.
Normal tissues showed weak to moderate cytoplasmic positivity with additional nuclear staining in several cases. Intestinal tract and exocrine pancreas displayed strong cytoplasmic staining while non-germinal center cells exhibited strong nuclear positivity. Parathyroid displayed nuclear, cytoplasmic and membranous immunoreactivity. Bile duct cells, reaction center cells, myocytes and most cells in CNS were weakly stained or negative.
Normal cells showed moderate to strong cytoplasmic with additional nuclear and/or membranous immunoreactivity in many cases.