CLDN8

GENE INFORMATION

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Gene name

CLDN8

Synonyms

Description

claudin 8 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This protein plays important roles in the paracellular cation barrier of the distal renal tubule, and in the paracellular barrier to prevent sodium back-leakage in distal colon. Differential expression of this gene has been observed in colorectal carcinoma and renal cell tumors, and along with claudin-7, is an immunohistochemical marker for the differential diagnosis of chromophobe renal cell carcinoma and renal oncocytoma.[provided by RefSeq, May 2010]

Chromosome

21 (Chromosome progress)

Cytoband

q22.11

Chromosome location (bp)

31586324 - 31588391

Ensembl

ENSG00000156284 (version 73.37)

Entrez gene

9073

UniProt

P56748 (UniProt - Evidence at transcript level)

neXtProt

NX_P56748

Antibodypedia

CLDN8 antibodies
 

PROTEIN VIEW

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CLDN8-001
 
CLDN8-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CLDN8-001 ENSP00000382783
ENST00000399899
P56748
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Show » Show » 225 24.8 No 4
CLDN8-201 ENSP00000286809
ENST00000286809
P56748
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Show » Show » 225 24.8 No 4