The cancer tissue page shows antibody staining in 20 different cancers. The overall cancer tissue staining statistics shows the fraction of patient samples with strong, moderate, weak or no staining (as described by the color-coding scale in the box to the right), using all the available antibodies to the protein targets encoded by this gene. The assay and annotation is described here.
The cancers can be ordered histologically or alphabetically.
For each cancer, the staining for each available antibody is reported as the fraction of samples with strong, moderate, weak or no staining (as described by the color-coding scale in the box to the right). The lenght of the bar represents the number of patient samples analysed (max=12 patients). By clicking on a cancer tissue, the detailed staining data for that cancer is available, including annotated images.
At the bottom of this page, a summary for the cancer staining for each antibody is given, together with the immunohistochemistry validation score for that antibody.
Many cases of breast, prostate, malignant melanomas, urothelial and lung cancers exhibited moderate to strong cytoplasmic immunoreactivity. The remaining tumors were generally negative.
A majority of malignant tissues displayed moderate to strong cytoplasmic staining often with a granular pattern. Renal carcinomas were negative. Cholangiocarcinomas were in general strongly stained whereas hepatocellular cancers were negative.
Malignant cells generally displayed moderate or strong cytoplasmic staining.
Most malignancies exhibited weak cytoplasmic staining or were negative. Several breast and liver cancers displayed moderate positivity.
Validation
Two (or more) antibodies yielding similar staining patterns which are consistent with available gene/protein characterization data
Two (or more) antibodies yielding similar staining patterns which are consistent with available gene/protein characterization data
Two (or more) antibodies yielding partly similar staining patterns which are consistent with gene/protein characterization data
The multi-targeting antibody yielding a staining pattern consistent with gene/protein characterization data for at least one of the genes whereas any of the other genes has no available gene/protein characterization data or is contradicted by gene/protein
