HK1

GENE INFORMATION

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Gene name

HK1

Synonyms

Description

hexokinase 1 (HGNC Symbol)

Entrez gene summary

Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes a ubiquitous form of hexokinase which localizes to the outer membrane of mitochondria. Mutations in this gene have been associated with hemolytic anemia due to hexokinase deficiency. Alternative splicing of this gene results in five transcript variants which encode different isoforms, some of which are tissue-specific. Each isoform has a distinct N-terminus; the remainder of the protein is identical among all the isoforms. A sixth transcript variant has been described, but due to the presence of several stop codons, it is not thought to encode a protein. [provided by RefSeq, Apr 2009]

Chromosome

10 (Chromosome progress)

Cytoband

q22.1

Chromosome location (bp)

71029740 - 71161638

Ensembl

ENSG00000156515 (version 73.37)

Entrez gene

3098

UniProt

P19367 (UniProt - Evidence at protein level)

neXtProt

NX_P19367

Antibodypedia

HK1 antibodies
 

PROTEIN VIEW

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HK1-001
 
HK1-003
 
HK1-004
 
HK1-016
 
HK1-201
 
HK1-202
 
HK1-203
 
HK1-204
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HK1-001 ENSP00000352398
ENST00000359426
P19367
Show all »
Show » Show » 917 102.5 No 0
HK1-003 ENSP00000409761
ENST00000450646
B1AR61
Show all »
Show » 139 15.7 No 0
HK1-004 ENSP00000398316
ENST00000421088
B1AR62
Show all »
Show » 114 13 No 0
HK1-016 ENSP00000415949
ENST00000436817
B1AR63
Show all »
Show » 291 32.7 No 0
HK1-201 ENSP00000298649
ENST00000298649
P19367
Show all »
Show » Show » 916 102.2 No 0
HK1-202 ENSP00000353433
ENST00000360289
P19367
Show all »
Show » Show » 905 101.1 No 0
HK1-203 ENSP00000384774
ENST00000404387
P19367
Show all »
Show » Show » 921 102.7 No 0
HK1-204 ENSP00000402103
ENST00000448642
E7ENR4
Show all »
Show » Show » 952 106.3 No 0