FRRS1

GENERAL INFORMATION

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Gene name

FRRS1

Gene description

Ferric-chelate reductase 1

Protein class

Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Mixed
GTEx:Mixed

Protein evidence

Evidence at protein level

Protein localization

A majority of normal cells showed moderate cytoplasmic staining. Epididymis were strongly stained. Pancreas, squamous epithelia, cervix and fallopian tube were weakly stained or negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA017883
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Epididymis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Mixed

Organ

Expression

GTEx dataset
RNA tissue category:  Mixed

Organ

Expression



GENE INFORMATION

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Gene name

FRRS1 (HGNC Symbol)

Synonyms

SDFR2, SDR2

Description

Ferric-chelate reductase 1 (HGNC Symbol)

Entrez gene summary

Members of the cytochrome b561 (CYB561; MIM 600019) family, including FRRS1, reduce ferric to ferrous iron before its transport from the endosome to the cytoplasm (Vargas et al., 2003 [PubMed 14499595]).[supplied by OMIM, Mar 2008]

Chromosome

1

Cytoband

p21.2

Chromosome location (bp)

99708703 - 99766631

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000156869 (version 78.38)

Entrez gene

391059

UniProt

Q6ZNA5 (UniProt - Evidence at transcript level)

neXtProt

NX_Q6ZNA5

Antibodypedia

FRRS1 antibodies


PROTEIN BROWSER

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ENST00000287474
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

FRRS1-001 ENSP00000287474
ENST00000287474
Q6ZNA5
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