GPR112

GENERAL INFORMATION

? »

Gene name

GPR112

Gene description

G protein-coupled receptor 112

Protein class

G-protein coupled receptors
Plasma proteins
Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

? »

RNA tissue category

HPA:Tissue enhanced (duodenum, small intestine)
GTEx:Tissue enhanced (fallopian tube)

Protein evidence

Evidence at protein level

Protein localization

RNA data suggests tissue enhanced expression in duodenum and small intestine. RNA-based expert annotation gave inconclusive results.

ANTIBODY RELIABILITY

? »

Data reliability
description

Presumed off target binding observed and disregarded. Pending external verification.

Data reliability

Uncertain based on 1 antibody.
HPA035324
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

? »
RNA expression (FPKM) Protein expression (score)
Brain
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Kidney & urinary bladder
N/A
Male tissues
N/A
Testis
N/A
Epididymis
N/A
N/A
Prostate
N/A
Seminal vesicle
N/A
N/A
Female tissues
N/A
Breast
N/A
N/A
Vagina
N/A
N/A
Cervix, uterine
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Skin
N/A
Skin
N/A
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

? »
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.


RNA EXPRESSION OVERVIEW

? »
HPA dataset
RNA tissue category:  Tissue enhanced (duodenum, small intestine)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (fallopian tube)

Organ

Expression



GENE INFORMATION

? »

Gene name

GPR112 (HGNC Symbol)

Synonyms

PGR17, RP1-299I16

Description

G protein-coupled receptor 112 (HGNC Symbol)

Entrez gene summary

This gene encodes a G-protein coupled receptor belonging to a large family of diverse integral membrane proteins that participate in various physiological functions. Members of this superfamily are characterized by a signature 7-transmembrane domain motif. The ligand for this family member is unknown, and it is therefore an orphan receptor. This receptor is known to be expressed in normal enterochromaffin cells and in gastrointestinal neuroendocrine carcinoma cells, and it is therefore considered to be a novel biomarker or target for immunotherapy. [provided by RefSeq, May 2010]

Chromosome

X

Cytoband

q26.3

Chromosome location (bp)

136300963 - 136416888

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000156920 (version 78.38)

Entrez gene

139378

UniProt

Q8IZF6 (UniProt - Evidence at transcript level)

neXtProt

NX_Q8IZF6

Antibodypedia

GPR112 antibodies


PROTEIN BROWSER

? »
 
 
 
ENST00000370652
 
ENST00000394141
 
ENST00000394143
 
 
 
 


PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GPR112-002 ENSP00000377697
ENST00000394141
Q8IZF6
Show all »
Show » Show » 2875 309.4 No 7
GPR112-003 ENSP00000377699
ENST00000394143
Q8IZF6
Show all »
Show » Show » 3080 333.4 No 7
GPR112-201 ENSP00000359686
ENST00000370652
Q8IZF6
Show all »
Show » Show » 3080 333.4 No 7