NTAN1

GENE INFORMATION

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Gene name

NTAN1

Synonyms

Description

N-terminal asparagine amidase (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene functions in a step-wise process of protein degradation through the N-end rule pathway. This protein acts as a tertiary destabilizing enzyme that deamidates N-terminal L-Asn residues on proteins to produce N-terminal L-Asp. L-Asp substrates are subsequently conjugated to L-Arg, which is recognized by specific E3 ubiquitin ligases and targeted to the proteasome. Pseudogenes of this gene are located on the long arms of chromosomes 8, 10 and 12. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]

Chromosome

16

Cytoband

p13.11

Chromosome location (bp)

15131710 - 15149921

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000157045 (version 75.37)

Entrez gene

123803

UniProt

Q96AB6 (UniProt - Evidence at protein level)

neXtProt

NX_Q96AB6

Antibodypedia

NTAN1 antibodies
 

PROTEIN VIEW

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NTAN1-001
 
NTAN1-002
 
NTAN1-004
 
NTAN1-006
 
NTAN1-007
 
NTAN1-008
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

NTAN1-001 ENSP00000287706
ENST00000287706
Q96AB6
Show all »
Show » Show » 310 34.7 No 0
NTAN1-002 ENSP00000457467
ENST00000565187
H3BU50
Show all »
Show » 45 5.1 No 0
NTAN1-004 ENSP00000456142
ENST00000563940
H3BR97
Show all »
Show » 27 3.1 No 0
NTAN1-006 ENSP00000455396
ENST00000568320
H3BPN7
Show all »
Show » Show » 146 16.8 No 0
NTAN1-007 ENSP00000454883
ENST00000566419
H3BNJ5
Show all »
Show » Show » 223 25.1 No 0
NTAN1-008 ENSP00000454595
ENST00000568738
Show » 18 2 No 0