ATP2B2

GENE INFORMATION

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Gene name

ATP2B2 (HGNC Symbol)

Synonyms

PMCA2

Description

ATPase, Ca++ transporting, plasma membrane 2 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 2. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Chromosome

3 (Chromosome progress)

Cytoband

p25.3

Chromosome location (bp)

10365707 - 10749716

Ensembl

ENSG00000157087 (version 73.37)

Entrez gene

491

UniProt

Q01814 (UniProt - Evidence at protein level)

neXtProt

NX_Q01814

Antibodypedia

ATP2B2 antibodies
 

PROTEIN VIEW

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ATP2B2-001
 
ATP2B2-002
 
ATP2B2-003
 
ATP2B2-004
 
ATP2B2-005
 
ATP2B2-201
 
ATP2B2-202
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ATP2B2-001 ENSP00000324172
ENST00000352432
Q01814
Show all »
Show » Show » 1243 136.9 No >9
ATP2B2-002 ENSP00000373311
ENST00000383800
Q01814
Show all »
Show » Show » 1198 132.6 No >9
ATP2B2-003 ENSP00000414854
ENST00000452124
H0Y7S3
Show all »
Show » Show » 1099 121.3 No 9
ATP2B2-004 ENSP00000424494
ENST00000460129
Q01814
Show all »
Show » Show » 1154 127.3 No >9
ATP2B2-005 ENSP00000380267
ENST00000397077
Q01814
Show all »
Show » Show » 1198 132.6 No >9
ATP2B2-201 ENSP00000344677
ENST00000343816
Q01814
Show all »
Show » Show » 1229 135.4 No >9
ATP2B2-202 ENSP00000353414
ENST00000360273
Q01814
Show all »
Show » Show » 1243 136.9 No >9