KIT

GENE INFORMATION

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Gene name

KIT (HGNC Symbol)

Synonyms

C-Kit, CD117, PBT, SCFR

Description

v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog (HGNC Symbol)

Entrez gene summary

This gene encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. This protein is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

4 (Chromosome progress)

Cytoband

q12

Chromosome location (bp)

55524085 - 55606881

Ensembl

ENSG00000157404 (version 73.37)

Entrez gene

3815

UniProt

P10721 (UniProt - Evidence at protein level)

neXtProt

NX_P10721

Antibodypedia

KIT antibodies
 

PROTEIN VIEW

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KIT-001
 
KIT-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

KIT-001 ENSP00000288135
ENST00000288135
P10721
Show all »
Show » Show » 976 109.9 Yes 1
KIT-002 ENSP00000390987
ENST00000412167
P10721
Show all »
Show » Show » 972 109.5 Yes 1