DYRK1A

GENE INFORMATION

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Gene name

DYRK1A (HGNC Symbol)

Synonyms

DYRK, DYRK1, MNBH

Description

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms. [provided by RefSeq, Jul 2008]

Chromosome

21 (Chromosome progress)

Cytoband

q22.13

Chromosome location (bp)

38739236 - 38887680

Ensembl

ENSG00000157540 (version 73.37)

Entrez gene

1859

UniProt

Q13627 (UniProt - Evidence at protein level)

neXtProt

NX_Q13627

Antibodypedia

DYRK1A antibodies
 

PROTEIN VIEW

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DYRK1A-001
 
DYRK1A-003
 
DYRK1A-004
 
DYRK1A-005
 
DYRK1A-006
 
DYRK1A-008
 
DYRK1A-201
 
DYRK1A-202
 
DYRK1A-203
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DYRK1A-001 ENSP00000342690
ENST00000338785
Q13627
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Show » Show » 584 66.1 No 0
DYRK1A-003 ENSP00000340373
ENST00000339659
Q13627
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Show » Show » 754 84.6 No 0
DYRK1A-004 ENSP00000398483
ENST00000455097
Q76N25
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Show » 46 5 No 0
DYRK1A-005 ENSP00000412269
ENST00000426672
E7EMI5
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Show » 131 14.9 No 0
DYRK1A-006 ENSP00000381932
ENST00000398960
Q13627
Show all »
Show » Show » 763 85.6 No 0
DYRK1A-008 ENSP00000381929
ENST00000398956
Q13627
Show all »
Show » Show » 529 60.3 No 0
DYRK1A-201 ENSP00000319032
ENST00000321219
F8W9I9
Show all »
Show » Show » 541 61.9 No 0
DYRK1A-202 ENSP00000416089
ENST00000451934
Q13627
Show all »
Show » Show » 584 66.1 No 0
DYRK1A-203 ENSP00000407854
ENST00000455387
F8WAP0
Show all »
Show » Show » 535 59 No 0