TAB3

GENERAL INFORMATION

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Gene name

TAB3

Gene description

TGF-beta activated kinase 1/MAP3K7 binding protein 3

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

4
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic and nuclear expression in many tissues.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 2 antibodies.
HPA034980 , HPA034981
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

TAB3 (HGNC Symbol)

Synonyms

MAP3K7IP3

Description

TGF-beta activated kinase 1/MAP3K7 binding protein 3 (HGNC Symbol)

Entrez gene summary

The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

Chromosome

X

Cytoband

p21.2

Chromosome location (bp)

30827442 - 30975084

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000157625 (version 78.38)

Entrez gene

257397

UniProt

Q8N5C8 (UniProt - Evidence at protein level)

neXtProt

NX_Q8N5C8

Antibodypedia

TAB3 antibodies


PROTEIN BROWSER

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ENST00000288422
 
ENST00000378930
 
ENST00000378932
 
ENST00000378933
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TAB3-001 ENSP00000368215
ENST00000378933
Q8N5C8
Show all »
Show » Show » 712 78.7 No 0
TAB3-004 ENSP00000368214
ENST00000378932
Q8N5C8
Show all »
Show » Show » 684 75.6 No 0
TAB3-006 ENSP00000288422
ENST00000288422
Show » Show » 47 5.3 No 0
TAB3-201 ENSP00000368212
ENST00000378930
Q8N5C8
Show all »
Show » Show » 712 78.7 No 0