BRAF

GENE INFORMATION

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Gene name

BRAF (HGNC Symbol)

Synonyms

BRAF1

Description

v-raf murine sarcoma viral oncogene homolog B (HGNC Symbol)

Entrez gene summary

This gene encodes a protein belonging to the raf/mil family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene are associated with cardiofaciocutaneous syndrome, a disease characterized by heart defects, mental retardation and a distinctive facial appearance. Mutations in this gene have also been associated with various cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma, non-small cell lung carcinoma, and adenocarcinoma of lung. A pseudogene, which is located on chromosome X, has been identified for this gene. [provided by RefSeq, Jul 2008]

Chromosome

7 (Chromosome progress)

Cytoband

q34

Chromosome location (bp)

140424943 - 140624564

Ensembl

ENSG00000157764 (version 73.37)

Entrez gene

673

UniProt

P15056 (UniProt - Evidence at protein level)

neXtProt

NX_P15056

Antibodypedia

BRAF antibodies
 

PROTEIN VIEW

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BRAF-001
 
BRAF-002
 
BRAF-003
 
BRAF-005
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

BRAF-001 ENSP00000288602
ENST00000288602
P15056
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Show » Show » 766 84.4 No 0
BRAF-002 ENSP00000420119
ENST00000497784
H7C5K3
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Show » Show » 194 20.9 No 0
BRAF-003 ENSP00000419060
ENST00000496384
E5FF37
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Show » Show » 375 41.8 No 0
BRAF-005 ENSP00000418033
ENST00000479537
H7C4S5
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Show » Show » 102 11.9 No 0