ADAMTS4

GENE INFORMATION

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Gene name

ADAMTS4 (HGNC Symbol)

Synonyms

ADAMTS-2, ADMP-1, KIAA0688

Description

ADAM metallopeptidase with thrombospondin type 1 motif, 4 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. It is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system, potentially, in the progression of glioma. [provided by RefSeq, Jul 2008]

Chromosome

1 (Chromosome progress)

Cytoband

q23.3

Chromosome location (bp)

161159538 - 161168846

Ensembl

ENSG00000158859 (version 73.37)

Entrez gene

9507

UniProt

O75173 (UniProt - Evidence at protein level)

neXtProt

NX_O75173

Antibodypedia

ADAMTS4 antibodies
 

PROTEIN VIEW

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ADAMTS4-001
 
ADAMTS4-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ADAMTS4-001 ENSP00000356975
ENST00000367996
O75173
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Show » Show » 837 90.2 No 0
ADAMTS4-002 ENSP00000356974
ENST00000367995
Q5VTW1
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Show » Show » 339 36 No 0