IFNAR2

GENERAL INFORMATION

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Gene name

IFNAR2

Gene description

Interferon (alpha, beta and omega) receptor 2

Protein class

Cancer-related genes
FDA approved drug targets
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

Intracellular,Membrane

Number of transcripts

7
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

The brushborder in placental trophoblasts and subsets of endometrial glandular cells were strongly stained. Gastric mucosa, rectum, prostate and subset of lymphoid cells showed weak to moderate cytoplasmic immunoreactivity. Remaining normal tissues were generally negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
CAB025889
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Bone marrow

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

IFNAR2 (HGNC Symbol)

Synonyms

IFNABR

Description

Interferon (alpha, beta and omega) receptor 2 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. Multiple transcript variants encoding at least two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

21

Cytoband

q22.11

Chromosome location (bp)

33229901 - 33265675

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000159110 (version 78.38)

Entrez gene

3455

UniProt

P48551 (UniProt - Evidence at protein level)

neXtProt

NX_P48551

Antibodypedia

IFNAR2 antibodies


PROTEIN BROWSER

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ENST00000342101
 
ENST00000342136
 
ENST00000382264
 
ENST00000404220
 
ENST00000413881
 
ENST00000443073
 
ENST00000447980
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

IFNAR2-001 ENSP00000384309
ENST00000404220
P48551
Show all »
Show » Show » 331 37.4 No 1
IFNAR2-002 ENSP00000343957
ENST00000342136
P48551
Show all »
Show » Show » 515 57.8 No 2
IFNAR2-003 ENSP00000343289
ENST00000342101
P48551
Show all »
Show » Show » 239 27.4 No 0
IFNAR2-004 ENSP00000371699
ENST00000382264
P48551
Show all »
Show » Show » 331 37.4 No 1
IFNAR2-008 ENSP00000402311
ENST00000447980
C9JM33
Show all »
Show » Show » 204 23.5 No 1
IFNAR2-009 ENSP00000413160
ENST00000413881
C9K067
Show all »
Show » Show » 167 19 No 0
IFNAR2-010 ENSP00000403569
ENST00000443073
C9JCU0
Show all »
Show » Show » 229 25.8 No 1