ACE

GENE INFORMATION

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Gene name

ACE (HGNC Symbol)

Synonyms

ACE1, CD143, DCP1

Description

angiotensin I converting enzyme (HGNC Symbol)

Entrez gene summary

This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, and two most abundant spliced variants encode the somatic form and the testicular form, respectively, that are equally active. [provided by RefSeq, May 2010]

Chromosome

17 (Chromosome progress)

Cytoband

q23.3

Chromosome location (bp)

61554422 - 61599205

Ensembl

ENSG00000159640 (version 73.37)

Entrez gene

1636

UniProt

P12821 (UniProt - Evidence at protein level)

neXtProt

NX_P12821

Antibodypedia

ACE antibodies
 

PROTEIN VIEW

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 « 
 
ACE-001
 
ACE-003
 
ACE-006
 
ACE-007
 
ACE-008
 
ACE-009
 
ACE-011
 
ACE-012
 
ACE-013
 
ACE-014
 
ACE-015
 
ACE-017
 
ACE-020
 
ACE-201
 
ACE-202
 
ACE-203
 
ACE-204
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ACE-001 ENSP00000290866
ENST00000290866
P12821
Show all »
Show » Show » 1306 149.7 Yes 1
ACE-003 ENSP00000462995
ENST00000582678
J3KTH9
Show all »
Show » 168 18.1 Yes 0
ACE-006 ENSP00000462599
ENST00000579314
J3KSQ5
Show all »
Show » Show » 208 23.1 Yes 0
ACE-007 ENSP00000290863
ENST00000290863
P12821
Show all »
Show » Show » 732 83.3 Yes 1
ACE-008 ENSP00000462110
ENST00000578839
J3QSC7
Show all »
Show » 44 4.5 Yes 0
ACE-009 ENSP00000392247
ENST00000413513
P12821
Show all »
Show » Show » 691 78.7 Yes 1
ACE-011 ENSP00000462280
ENST00000582627
J3KS28
Show all »
Show » 314 35.5 No 0
ACE-012 ENSP00000463302
ENST00000580318
J3QKZ3
Show all »
115 12.4 No 0
ACE-013 ENSP00000463673
ENST00000579726
Show » 119 13 No 0
ACE-014 ENSP00000462002
ENST00000582005
J3KRH5
Show all »
Show » Show » 145 15.7 Yes 0
ACE-015 ENSP00000464629
ENST00000579204
J3QSC7
Show all »
Show » 36 3.9 Yes 0
ACE-017 ENSP00000462909
ENST00000582761
J3KTB8
Show all »
Show » 282 33 No 0
ACE-020 ENSP00000464428
ENST00000579409
Show » 138 15.4 No 0
ACE-201 ENSP00000387760
ENST00000421982
F6X3S4
Show all »
Show » Show » 511 58.5 No 1
ACE-202 ENSP00000397593
ENST00000428043
P12821
Show all »
Show » Show » 1145 131.7 Yes 0
ACE-203 ENSP00000464539
ENST00000490216
L7MUH0
Show all »
Show » Show » 739 84 Yes 0
ACE-204 ENSP00000439591
ENST00000538928
F5H1K1
Show all »
Show » 475 53.8 Yes 0